Educació en competències: TFG-Farmàcia
Castilla, Clàudia; Alegret, Marta
Abstract
Recent studies suggest that excessive consumption of fructose is involved in alterations at the level of the
cortex and/or hippocampus, areas that are responsible for language comprehension, memory and learning.
In this paper, we study the effect of supplementation with 10% (w/v) glucose or fructose in drinking water
for seven months on insulin signalling pathways in the cortex and the emergence of cognitive disorders in
female rats. The results show that while glucose provides the same amount of calories, only the rats supplemented
with fructose showed a reduction in the levels of key proteins in the insulin signalling pathway in
the cortex and in the levels of the neurogenic protein BDNF, along with cognitive alterations observed in the
novel object recognition test. Therefore, we conclude that these changes occur due to additional mechanisms
to caloric excess.
Keywords: fructosa, begudes edulcorades, alteracions cognitives, insulina.
Reception date: 29/09/2016
Acceptance date: 28/10/2016