Corpora amylacea (CA) are granular bodies that accumulate in the human brain during aging and neurodegenerative conditions. These structures act as containers that amass waste substances from the brain and they are extruded from the central nervous system to the cerebrospinal fluid (CSF). From the CSF, they reach the cervical lymph nodes, where they can be phagocytosed by macrophages. In this work, human CSF samples and THP-1 derived macrophages were processed by immunofluorescence techniques to study the presence of phagocytosis inducers on the surface of CA, as well as macrophage surface receptors. The results suggest that CA can be phagocytosed by means of the mannose binding lectin, which attaching these bodies would cause a C3b-opsonization. Furthermore, macrophages derived from THP-1 monocytes present C3b receptors that would recognize the C3b that opsonize the CA.