A typikon, stored in the National Library of the University of Turin under the signature C iii 17 (gr. 216), portrays the industrious cultural activity of the monastery of St. Nicholas of Casole (gr. ton Kasoulon), founded in 1098/99 by the monk Joseph, thanks to the patronage of Bohemund, prince of Taranto and Antioch, about a few miles south of Otranto (Lecce), in the south-eastern tip of Italy. According to the testimony of the manuscript, it can be given a broad outline of the scriptorium’s daily activity as a crucial centre of culture and knowledge’s transmission through the manuscripts’ copying. This factor allowed a substantial diffusion of texts both in the religious either in the secular milieu, by making the Hydruntine coenobium to become one of the Byzantine culture’s most outstanding centres in Southern Italy.